Integrated Multi‐Omics Reveals Cellular States and Microenvironmental Remodeling in Coexisting DCIS and IDC
Ning Zhang, Tong Wan, Siyue Zhang, Yunzhen Jiang, Peng Su, Jixin Liu, Zhitong Chen, Jie Hao, Haoyu Wang, Bing Chen, Wenjing Zhao, Lijuan Wang · 2026
Read Integrated Multi‐Omics Reveals Cellular States and Microenvironmental Remodeling in Coexisting DCIS and IDC by Ning Zhang, Tong Wan, Siyue Zhang, Yunzhen Jiang, Peng Su, Jixin Liu, Zhitong Chen, Jie Hao, Haoyu Wang, Bing Chen, Wenjing Zhao, Lijuan Wang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13616352.txt.
Description
Ning Zhang and colleagues combine three kinds of single-cell and tissue mapping to trace how a non-invasive breast lesion turns invasive. Their samples hold both stages side by side in the same breast. Ductal carcinoma in situ stays inside the milk ducts, while its invasive cousin breaks out, and what tips one into the other is still murky. Spatial gene maps, single-cell RNA readings, and single-cell DNA readings were layered on the same tissue.
The two stages showed distinct molecular faces, and three genes, named MGP, PLAT, and SERPINA3, stood out as possible brakes on invasion. Cancer cell programs split by theme: a development-like program ruled the in situ stage, while a cell-division program ruled the invasive stage. The surrounding tissue also changed character between stages, giving doctors candidate markers for judging which quiet lesions may turn dangerous.
Catalog record
| CREATOR | Ning Zhang, Tong Wan, Siyue Zhang, Yunzhen Jiang, Peng Su, Jixin Liu, Zhitong Chen, Jie Hao, Haoyu Wang, Bing Chen, Wenjing Zhao, Lijuan Wang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 82 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |