Tailless terminates the neural stem cell temporal cascade in both the optic lobe and central brain
Jocelyn L Y Tang, Alex P A Donovan, Andrea H Brand · 2026
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Description
Jocelyn Tang, Alex Donovan, and Andrea Brand report, in a 2026 study, that one gene ends the production line of new neurons in two parts of the fly brain. Developing brains stamp out cell types in sequence, driven by a relay of timing factors. The visual system's stem cells end their relay with a factor called Tailless.
The team found the same factor closing the relay in central-brain progenitors too. A preceding factor switches it on, and it silences an earlier program. When the relay ends, neuron birth stops and support-cell birth begins. Finding the same closing act in two lineages suggests a conserved choreography for finishing a brain.
Catalog record
| CREATOR | Jocelyn L Y Tang, Alex P A Donovan, Andrea H Brand |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 44 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |