AI-powered histopathology classifiers identify transcriptomic biomarkers associated with cell cycle regulation and increased mitotic activity in poorly differentiated neuroendocrine carcinoma
Timothy Khumpan, Kasonde Chewe, Namrata Vijayvergia, Eric Eleam, Juan Nicolas Quiñones-Romero, Suraj Peri, Gong Yulan, Paul F Engstrom, Kathy Q Cai, Jianming Pei, Gulnaz D Alekbaeva, Kerry S Campbell, Johnathan R Whetstine, Igor Astsaturov, Hayan Lee · 2026
Read AI-powered histopathology classifiers identify transcriptomic biomarkers associated with cell cycle regulation and increased mitotic activity in poorly differentiated neuroendocrine carcinoma by Timothy Khumpan, Kasonde Chewe, Namrata Vijayvergia, Eric Eleam, Juan Nicolas Quiñones-Romero, Suraj Peri, Gong Yulan, Paul F Engstrom, Kathy Q Cai, Jianming Pei, Gulnaz D Alekbaeva, Kerry S Campbell, Johnathan R Whetstine, Igor Astsaturov, Hayan Lee (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13615580.txt.
Description
Timothy Khumpan and a large team of co-authors published this 2026 study on telling apart two kinds of neuroendocrine tumors. These cancers arise from hormone-making cells in many organs, and sorting the fast, deadly carcinomas from the slow tumors matters because treatment and outlook differ sharply. Standard microscopy often cannot make the call alone.
The team profiled gene activity in 36 tumors from eleven body sites and trained an AI classifier on the tissue images. The classifier scored between 0.87 and 0.93 on the standard accuracy curve. Gene markers tied to the cell cycle and to rapid cell division marked the aggressive group. The work points toward molecularly informed diagnosis for these rare cancers.
Catalog record
| CREATOR | Timothy Khumpan, Kasonde Chewe, Namrata Vijayvergia, Eric Eleam, Juan Nicolas Quiñones-Romero, Suraj Peri, Gong Yulan, Paul F Engstrom, Kathy Q Cai, Jianming Pei, Gulnaz D Alekbaeva, Kerry S Campbell, Johnathan R Whetstine, Igor Astsaturov, Hayan Lee |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 53 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |