MalDeepSeq panel: A targeted ultra-deep sequencing approach to trace drug resistance markers in Plasmodium falciparum
Yanka EA R Salazar, Antonio M Rezende, Maria CS B Puça, Sonja Lagström, Danielle Fletcher, Julian Muwanguzi-Karugaba, Colin J Sutherland, Khalid B Beshir, Maria EP Mascarenhas, Jaime Louzada, Joseli Oliveira-Ferreira, Abdoulaye Djimde, Dinora Lopes, Tais N de Sousa, José P Gil · 2026
Read MalDeepSeq panel: A targeted ultra-deep sequencing approach to trace drug resistance markers in Plasmodium falciparum by Yanka EA R Salazar, Antonio M Rezende, Maria CS B Puça, Sonja Lagström, Danielle Fletcher, Julian Muwanguzi-Karugaba, Colin J Sutherland, Khalid B Beshir, Maria EP Mascarenhas, Jaime Louzada, Joseli Oliveira-Ferreira, Abdoulaye Djimde, Dinora Lopes, Tais N de Sousa, José P Gil (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13615499.txt.
Description
Yanka E. A. R. Salazar leads a team presenting in 2026 a targeted deep-sequencing panel, called MalDeepSeq, for tracing drug resistance in the malaria parasite Plasmodium falciparum. Resistance can hide in tiny minority parasite groups inside a patient before it spreads, so surveillance needs unusual depth. The panel reads the full length of 48 genes tied to resistance to malaria drugs.
The team checked it on lab mixtures of two parasite strains and on real patient samples, including dried blood spots. Two variant-calling programs reproduced the expected shares of each strain, one with less bias and error. A strict truth set gave perfect recall with no false alarms in control samples. Clinics and control programs gain a cheaper, sharper tool for spotting resistance while it is still rare.
Catalog record
| CREATOR | Yanka EA R Salazar, Antonio M Rezende, Maria CS B Puça, Sonja Lagström, Danielle Fletcher, Julian Muwanguzi-Karugaba, Colin J Sutherland, Khalid B Beshir, Maria EP Mascarenhas, Jaime Louzada, Joseli Oliveira-Ferreira, Abdoulaye Djimde, Dinora Lopes, Tais N de Sousa, José P Gil |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 60343 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |