A cardiometabolic risk phenotype index integrating insulin resistance, systemic inflammation, and psychological burden for mortality risk stratification in metabolic dysfunction-associated steatotic liver disease: an exploratory longitudinal analysis of a nationally representative cohort
Yan Chen, Kailing Xie, Ningkun Xiao, Haonan Ju, Qingzhi Zhou, Xin Zhao · 2026
Read A cardiometabolic risk phenotype index integrating insulin resistance, systemic inflammation, and psychological burden for mortality risk stratification in metabolic dysfunction-associated steatotic liver disease: an exploratory longitudinal analysis of a nationally representative cohort by Yan Chen, Kailing Xie, Ningkun Xiao, Haonan Ju, Qingzhi Zhou, Xin Zhao (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13613631.txt.
Description
Yan Chen and co-authors build a single risk index for fatty liver patients from three kinds of strain, in a 2026 paper. Fatty liver disease is a whole-body metabolic disorder, yet risk scores rarely mix its insulin, inflammation, and mood sides. Their ISP index braids insulin resistance markers, inflammation markers, and a depression score into one phenotype.
Data came from 3,187 adults with the disease in a national survey spanning 2005 to 2018. A random forest picked the strongest markers from candidate panels. Over about eight years of follow-up, 382 deaths occurred, letting the team test the index against overall and cardiovascular death with weighted survival models and machine learning checks. One number may triage who needs closest watching.
Catalog record
| CREATOR | Yan Chen, Kailing Xie, Ningkun Xiao, Haonan Ju, Qingzhi Zhou, Xin Zhao |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 66 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |