Simultaneous quantification of venetoclax, selinexor, voriconazole and fluconazole in human plasma by HPLC-MS/MS and its application in hematological malignancies
Feifei Han, Yinying Wang, Yuan Jian, Ting Hu, Ying Zhu, Xian Ding, Jinghui Zhang, Rao Wei, Honghu Zhu, Zhuoling An · 2026
Read Simultaneous quantification of venetoclax, selinexor, voriconazole and fluconazole in human plasma by HPLC-MS/MS and its application in hematological malignancies by Feifei Han, Yinying Wang, Yuan Jian, Ting Hu, Ying Zhu, Xian Ding, Jinghui Zhang, Rao Wei, Honghu Zhu, Zhuoling An (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13612908.txt.
Description
Han and co-authors build a single lab test that measures four drugs at once in blood plasma, in a 2026 paper. Two are targeted cancer drugs and two are antifungals often given alongside them. The antifungals change how the body handles the cancer drugs, so doctors need levels for all four to dose safely, especially in Chinese patients, whose drug handling differs.
The validated method proved accurate and free of interference. In patients, one antifungal raised cancer drug exposure anywhere from under twofold to fourteenfold, while the other raised it a steadier two to three times. A low cancer drug dose plus an antifungal matched a full dose alone.
Catalog record
| CREATOR | Feifei Han, Yinying Wang, Yuan Jian, Ting Hu, Ying Zhu, Xian Ding, Jinghui Zhang, Rao Wei, Honghu Zhu, Zhuoling An |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 34 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |