Gut microbiota dysbiosis is associated with hippocampal neuronal damage and behavioral alterations in APP/PS1 mice with high-salt diet
Huanmin Zhang, Jinxin Kou, Pengfei Ge, Lingzhuan Gong, Wen Zhang, Yulang Fei · 2026
Read Gut microbiota dysbiosis is associated with hippocampal neuronal damage and behavioral alterations in APP/PS1 mice with high-salt diet by Huanmin Zhang, Jinxin Kou, Pengfei Ge, Lingzhuan Gong, Wen Zhang, Yulang Fei (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13612445.txt.
Description
Huanmin Zhang and co-authors test in 2026 whether a long high salt diet worsens brain harm in mice bred to develop Alzheimer's like disease, through upset gut microbes. Salt is known to shift gut microbes and mood in normal mice, but its chronic effect in this disease was unclear. Mice got a normal or a very salty diet for six months starting at middle age, then faced behavior tests, brain tissue checks, and gut microbe profiling.
The salty diet tied to microbe imbalance, more inflammation signals in brain and liver, and loss of nerve cells and their branching in the memory center. Behavior shifted as well. The authors frame a gut to brain chain by which diet salt may speed decline.
Catalog record
| CREATOR | Huanmin Zhang, Jinxin Kou, Pengfei Ge, Lingzhuan Gong, Wen Zhang, Yulang Fei |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 45 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |