Associations of DTI-ALPS index and choroid plexus volume with clinical severity across the Parkinson’s disease spectrum
Yujue Wang, Zixuan Lin, Dan Wu, Ying Yang, Jing Zhang · 2026
Read Associations of DTI-ALPS index and choroid plexus volume with clinical severity across the Parkinson’s disease spectrum by Yujue Wang, Zixuan Lin, Dan Wu, Ying Yang, Jing Zhang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13612397.txt.
Description
Yujue Wang leads a five-author team tracking the brain's plumbing across the Parkinson's spectrum in 2026. If the glymphatic system fails to clear misfolded alpha-synuclein, the protein may accumulate and drive disease. Two MRI markers proxy that clearance: the DTI-ALPS index of perivascular water flow, and choroid plexus volume. The team analyzed 1,861 participants from a major progression cohort: 704 with Parkinson's, 997 prodromal, and 160 healthy controls.
The ALPS index fell stepwise from controls through prodromal participants to patients. It declined with age and ran lower in men. Lower values tracked worse motor severity in both groups, plus sleep behavior disorder, cognitive impairment, and depressive symptoms. Choroid plexus volume moved the other way, rising with severity, and the two markers correlated negatively. The authors read the pair as complementary gauges of a clearance system under strain. They propose both as staging biomarkers for clearance-targeted therapies.
Catalog record
| CREATOR | Yujue Wang, Zixuan Lin, Dan Wu, Ying Yang, Jing Zhang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 52385 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |