Systematic profiling of AGO2-associated circRNAs and functional investigation reveal circN4BP2L2 as a survival-promoting regulator in T-ALL
Monika Drobna-Sledzinska, Alessia Buratin, Eleonora Roncaglia, Alberto Caregari, Ilias Glogovitis, Maria Kosmalska, Xing Zhao, Silvia Bresolin, Enrico Gaffo, Anke Van den Berg, Joost Kluiver, Malgorzata Dawidowska, Stefania Bortoluzzi · 2026
Read Systematic profiling of AGO2-associated circRNAs and functional investigation reveal circN4BP2L2 as a survival-promoting regulator in T-ALL by Monika Drobna-Sledzinska, Alessia Buratin, Eleonora Roncaglia, Alberto Caregari, Ilias Glogovitis, Maria Kosmalska, Xing Zhao, Silvia Bresolin, Enrico Gaffo, Anke Van den Berg, Joost Kluiver, Malgorzata Dawidowska, Stefania Bortoluzzi (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13612239.txt.
Description
Monika Drobna-Sledzinska leads a thirteen-author team cataloguing circular RNAs in an aggressive blood cancer in 2026. T-cell acute lymphoblastic leukemia grows from immature T cells. Circular RNAs, looped molecules that can soak up regulatory microRNAs, are suspects in its machinery. The team fished out RNAs bound to the protein AGO2 in four leukemia cell lines, hunting for circles acting as microRNA sponges.
Circular RNAs were over-represented in the AGO2-bound fraction, 7.3 percent against 3 percent for linear RNAs, and a consistent enriched set emerged. One abundant circle, circN4BP2L2, also ran abnormal in patients. Knocking it down slowed cell proliferation, restored cell-death sensitivity, and shifted key leukemia pathways. Patient tumors with high levels of this circle showed gene-expression features overlapping the knockdown signature. The authors present circN4BP2L2 as a survival-promoting regulator, and the AGO2-bound catalog as a map for further targets.
Catalog record
| CREATOR | Monika Drobna-Sledzinska, Alessia Buratin, Eleonora Roncaglia, Alberto Caregari, Ilias Glogovitis, Maria Kosmalska, Xing Zhao, Silvia Bresolin, Enrico Gaffo, Anke Van den Berg, Joost Kluiver, Malgorzata Dawidowska, Stefania Bortoluzzi |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 45 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |