Synthesis and Broad-Spectrum Antiviral Evaluation of Novel 1,2,3-Triazole–Quinoline Derivatives Targeting SARS-CoV-2, Influenza, DENV-2, and CHIKV
Alcione Silva de Carvalho, Natalia Fintelman-Rodrigues, Victória Toledo Diniz de Camargo, Lina Silva-Trujillo, Caroline Souza de Freitas, Isabela Alencar Graciano, Acácio Silva de Souza, Camilla Blanco de Assis, Otávio Augusto Chaves, Fernando de Carvalho da Silva, Vitor F. Ferreira, Thiago Moreno L · 2026
Read Synthesis and Broad-Spectrum Antiviral Evaluation of Novel 1,2,3-Triazole–Quinoline Derivatives Targeting SARS-CoV-2, Influenza, DENV-2, and CHIKV by Alcione Silva de Carvalho, Natalia Fintelman-Rodrigues, Victória Toledo Diniz de Camargo, Lina Silva-Trujillo, Caroline Souza de Freitas, Isabela Alencar Graciano, Acácio Silva de Souza, Camilla Blanco de Assis, Otávio Augusto Chaves, Fernando de Carvalho da Silva, Vitor F. Ferreira, Thiago Moreno L (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13611932.txt.
Description
Four RNA viruses that keep re-emerging worldwide, from coronaviruses to dengue, share a need for new drugs that work across the family, and a fresh compound set was built for that hunt. Alcione Silva de Carvalho and co-authors report the set in this 2026 study. The compounds fuse two ring systems long known in drug chemistry.
The team synthesized the new molecules and tested them against the COVID virus, a pandemic flu strain, dengue type two, and chikungunya virus in cell assays. Broad-spectrum antivirals are prized because the next outbreak virus is unknown; a drug that hits a shared viral weak point could be stockpiled. The paper reports which structures showed the strongest and widest activity, guiding the next round of refinement.
Catalog record
| CREATOR | Alcione Silva de Carvalho, Natalia Fintelman-Rodrigues, Victória Toledo Diniz de Camargo, Lina Silva-Trujillo, Caroline Souza de Freitas, Isabela Alencar Graciano, Acácio Silva de Souza, Camilla Blanco de Assis, Otávio Augusto Chaves, Fernando de Carvalho da Silva, Vitor F. Ferreira, Thiago Moreno L |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 39 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |