Preclinical Evaluation of Novel Conserved Neisseria gonorrhoeae Vaccine Candidates Identified Through Infection-Informed Antigen Discovery
Shea K. Roe, Bo Zheng, Sunita Gulati, Sanjay Ram, Paola Massari · 2026
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Description
Shea Roe, Bo Zheng, Sunita Gulati, Sanjay Ram, and Paola Massari test early vaccine candidates against gonorrhea in a 2026 paper. The germ that causes this infection keeps gaining resistance to drugs, so a vaccine is badly needed. The team found six conserved proteins in the germ through a computer based search and test them in mice.
All six proteins drew strong antibody responses, and blood from immunized mice killed the germ in lab tests for several of them. A blend of three proteins drew even stronger responses than each one alone. Yet vaccinated mice cleared infection no faster than control mice, a gap the authors stress when ranking future targets.
Catalog record
| CREATOR | Shea K. Roe, Bo Zheng, Sunita Gulati, Sanjay Ram, Paola Massari |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 40 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |