Insights into Microbiota–Vaccine Crosstalk in Humans: Mechanisms, Modulators, and Translational Horizons
Ahmad R. Shakri, Sidharth P. Mishra, Sarina Lawless, Saswati Pani, Priyanka Mishra, Courtney L. Page, Gaurav Dutta, Chanchal Sharma · 2026
Read Insights into Microbiota–Vaccine Crosstalk in Humans: Mechanisms, Modulators, and Translational Horizons by Ahmad R. Shakri, Sidharth P. Mishra, Sarina Lawless, Saswati Pani, Priyanka Mishra, Courtney L. Page, Gaurav Dutta, Chanchal Sharma (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13611235.txt.
Description
Ahmad R Shakri and co-authors present a 2026 review of how gut microbes shape vaccine responses in humans. People answer the same vaccine very differently, and age, genes, and vaccine type explain only part of the spread. The authors gather human studies, microbe-targeted trials, and germ-free animal work to map the pathways involved.
Microbes may tune vaccines through immune sensors, early immune activation, antibody hubs, gut barrier strength, and chemical byproducts that steer immune cells. Effects vary with age and with vaccine kind, from live to mRNA types. Trials of probiotics and related products give mixed results so far. The authors call for long studies that can prove cause.
Catalog record
| CREATOR | Ahmad R. Shakri, Sidharth P. Mishra, Sarina Lawless, Saswati Pani, Priyanka Mishra, Courtney L. Page, Gaurav Dutta, Chanchal Sharma |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 84 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |