Studying Peripheral Neuropathy and Associated Neuropathic Pain in HIV-1 Transgenic Rats: Evaluation of the Therapeutic Effect of Cannabidiol and Beta-Caryophyllene
Mohammed Alnoud, Jose Rios, Salique H. Shaham, Manish K. Tripathi, Khalid Benamar · 2026
Read Studying Peripheral Neuropathy and Associated Neuropathic Pain in HIV-1 Transgenic Rats: Evaluation of the Therapeutic Effect of Cannabidiol and Beta-Caryophyllene by Mohammed Alnoud, Jose Rios, Salique H. Shaham, Manish K. Tripathi, Khalid Benamar (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13610690.txt.
Description
Alnoud and colleagues show in 2026 that rats carrying HIV genes develop nerve damage and pain much like people living with HIV, and test two cannabis compounds against it. The rats lost nerve fibers in skin and gained immune cells in nerve ganglia. They also showed pain-like behavior. Beta-caryophyllene eased the pain more than cannabidiol did, without central side effects.
Protein profiling found specific changes tied to the better compound's effect. The team says the rat offers a workable small model of HIV neuropathy, which affects up to half of patients. New pain treatments badly need such models.
Catalog record
| CREATOR | Mohammed Alnoud, Jose Rios, Salique H. Shaham, Manish K. Tripathi, Khalid Benamar |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 26 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |