Buccal Insulin Delivery Systems: Formulation Approaches, Stability Constraints, and Translational Prospects
Jahanvi Patel, Michael Stolinski, Anil Vangala · 2026
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Description
Jahanvi Patel and co-authors review insulin delivery through the cheek lining, a needle-free route chased for decades. The cheek offers a rich blood supply and skips the gut's acid bath. A working product, though, must solve five puzzles at once: stay put, cross mucus and skin, stay stable, dose evenly, and scale in factories.
The review grades the main platforms: sticky films and patches, nano carriers, bendy vesicles, chemical permeation tricks, and device aids. Most designs fix one puzzle and slight the rest. Insulin clumping and helper-ingredient decay get named as under-watched flaws. Lab promise keeps dying on low uptake, dose scatter, and safety flags. The authors argue that only builds that fuse entry, stability, and factory sense will reach patients.
Catalog record
| CREATOR | Jahanvi Patel, Michael Stolinski, Anil Vangala |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 53 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |