Mucoadhesive Nanoemulsions for Nose-to-Brain Delivery of Dimethyl Fumarate: Development, Characterization and Proof-of-Concept In Vivo Evaluation
Eleonora Sofia Cama, Giada Botti, Sara Perteghella, Laura Catenacci, Fahad Khan Tareen, Sarah Beggiato, Maria Cristina Bonferoni, Luca Ferraro, Milena Sorrenti, Alessandro Dalpiaz · 2026
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Description
Eleonora Sofia Cama and co-authors develop a nasal spray form of dimethyl fumarate, a drug used for multiple sclerosis, aimed at the brain. Published in 2026, the work seeks to dodge the gut side effects that often come with taking the drug by mouth. The drug calms inflammation and guards nerve cells.
The team made a nanoemulsion with geraniol as the oil phase and a chitosan based stabilizer that clings to the nose lining. Droplets were small and uniform, released the drug fast, and crossed cell layers well in lab tests. In rats, spray in the nose put the drug into the spinal fluid within two hours. The authors call it a proof of concept for nose to brain delivery.
Catalog record
| CREATOR | Eleonora Sofia Cama, Giada Botti, Sara Perteghella, Laura Catenacci, Fahad Khan Tareen, Sarah Beggiato, Maria Cristina Bonferoni, Luca Ferraro, Milena Sorrenti, Alessandro Dalpiaz |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 88 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |