Whole Genome Characterisation of Non-O1/Non-O139 Vibrio cholerae in Wastewater Treatment Plants in the Tshwane District, South Africa
Onalenna Ramocha, Selinah Idah Mulaudzi, John Yenga Bolukaoto, Siesta Rashopole, Kholofelo Malemela, Setshaba Taukobong, Maphoshane Nchabeleng, Renee Street, Andrew Munyalo Musyoki · 2026
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Description
Onalenna Ramocha and co-authors sequence cholera relatives found in South African wastewater, in a 2026 study. The strains lack the two classic toxin markers. They still cause gut illness, from mild to severe. After a cholera outbreak in the Tshwane district, the team sampled treatment plants. Three hundred forty-one wastewater samples were screened. Lab tests confirmed one hundred forty-three isolates of this milder group.
Fingerprinting sorted the isolates into twelve clusters. Twelve representatives went for full genome sequencing. Ten were confirmed as the target group. The genomes carried genes for toxins of other kinds and for survival tricks. Resistance to several first-line drugs appeared often. Six isolates carried plasmids loaded with resistance genes. Family analysis showed wide diversity among the strains. The authors warn these bacteria could still infect people. Steady wastewater surveillance is their recommendation.
Catalog record
| CREATOR | Onalenna Ramocha, Selinah Idah Mulaudzi, John Yenga Bolukaoto, Siesta Rashopole, Kholofelo Malemela, Setshaba Taukobong, Maphoshane Nchabeleng, Renee Street, Andrew Munyalo Musyoki |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 35 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |