Temporal Discordance of the Inflammation, Catabolism and Immunosuppression Triad in Chronic Critical Illness
Valery Likhvantsev, Levan Berikashvili, Petr Polyakov, Mikhail Yadgarov, Artem Kuzovlev, Alexey Yakovlev, Andrey Grechko · 2026
Read Temporal Discordance of the Inflammation, Catabolism and Immunosuppression Triad in Chronic Critical Illness by Valery Likhvantsev, Levan Berikashvili, Petr Polyakov, Mikhail Yadgarov, Artem Kuzovlev, Alexey Yakovlev, Andrey Grechko (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13609605.txt.
Description
Valery Likhvantsev and six co-authors charted in 2026 how three linked problems unfold over time in chronic critical illness. Long-stay intensive care patients often show swelling, muscle wasting, and weak immunity at once. Whether those three move together was unknown. The team mined a Russian intensive care dataset covering 820 patients and over eighteen thousand patient-days.
Two domains, inflammation and low albumin, stayed switched on nearly all the time. Low lymphocyte counts, by contrast, came and went in short bursts. The lymphocyte domain disagreed with the other two on most days, while the first two largely agreed. Full recovery of all three at once was rare. The authors question treating the syndrome as one steady state and urge time-aware care.
Catalog record
| CREATOR | Valery Likhvantsev, Levan Berikashvili, Petr Polyakov, Mikhail Yadgarov, Artem Kuzovlev, Alexey Yakovlev, Andrey Grechko |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 35 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |