Plasma as Proxy for Tissue Metabolism When Extending Lifespan in Mice
Sara Greenfield, C. Titus Brown, Oliver Fiehn · 2026
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Description
Sara Greenfield, Titus Brown, and Oliver Fiehn ask how far a blood sample can stand in for the body's tissues in aging research. Their 2026 study profiles small molecules in mouse blood and five tissues after five treatments known to extend life, from calorie restriction to rapamycin. Blood is easy to draw, but whether it mirrors the organs was unclear.
Only about 37 percent of each tissue's molecules also appeared in blood. No single tissue dominated what blood showed. Calorie restriction left the widest shared footprint across organs and blood. A few compound families tracked well across four tissues and blood, and one aging-linked compound matched in blood and nearly all tissues. Males showed stronger blood-tissue agreement than females. The authors warn that blood is a partial mirror, not a window.
Catalog record
| CREATOR | Sara Greenfield, C. Titus Brown, Oliver Fiehn |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 44 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |