Integrated Multi-Omics Reveals Complementary Luminal and Mucosal Host–Microbiome Interactions Associated with Disease Activity and Phenotype in Paediatric Inflammatory Bowel Disease
Francesca Toto, Pamela Vernocchi, Paola De Angelis, Sara Isoldi, Salvatore Cucchiara, Laura Stronati, Lorenza Putignani, Federica Del Chierico · 2026
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Description
Francesca Toto and co-authors combined many kinds of biological data to study inflammatory bowel disease in children, in a 2026 study. The diseases, Crohn's disease and ulcerative colitis, arise from tangled interactions among the immune system, gut microbes, and body chemistry. The team sampled two gut compartments, the contents moving through the bowel and the lining itself.
Bacteria in the moving contents kept their broad structure, while active disease reshaped their makeup, their chemical outputs, and their ties to host markers. Differences between the two diseases showed up more in the lining, above all among fungi living there. The authors say the two compartments tell complementary stories. One tracks how active the disease is, the other which form it takes. Joining many data types is the way to read them.
Catalog record
| CREATOR | Francesca Toto, Pamela Vernocchi, Paola De Angelis, Sara Isoldi, Salvatore Cucchiara, Laura Stronati, Lorenza Putignani, Federica Del Chierico |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 47 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |