Clinical Subtype Stratification Reveals Gut Microbial Alterations, Candidate Markers, and Co-Occurrence Network Remodeling in Coronary Artery Disease
Peiqi Yan, Chen Tian, Lei Zhu, Zhigang Zhang, Oleg Paliy · 2026
Read Clinical Subtype Stratification Reveals Gut Microbial Alterations, Candidate Markers, and Co-Occurrence Network Remodeling in Coronary Artery Disease by Peiqi Yan, Chen Tian, Lei Zhu, Zhigang Zhang, Oleg Paliy (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13609194.txt.
Description
Peiqi Yan and four colleagues follow the gut microbiome across the stages of coronary artery disease. Gut imbalance is linked to heart disease, but how it shifts from mild narrowing to heart attack was unmapped. The team analyzed bacterial gene data from 306 people: healthy controls plus patients with mild coronary stenosis, stable angina, unstable angina, and heart attack. Diversity analysis, machine learning, and network modeling worked over the same data.
The microbial community changed most sharply at the heart attack stage. Three bacteria emerged as stage markers: Veillonella for mild stenosis, Intestinimonas for stable angina, and Streptococcus for unstable angina and heart attack. Network connections thinned from mild disease through unstable angina, then flipped to an antagonism-dominated web during heart attack. Machine learning separated the stages well, and the marker bacteria stayed significant after accounting for major clinical factors. Stage-specific stool markers could aid staging, the authors propose.
Catalog record
| CREATOR | Peiqi Yan, Chen Tian, Lei Zhu, Zhigang Zhang, Oleg Paliy |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 50 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |