Hepatic ChREBP Drives Cardiac Remodeling via ApoM Non-transcriptional Repression
Shuang Zhang, Zhenzhen Zhang, Zihan Ma, Wen Wu, Lu Tang, Yanlu Han, Songning Chen, Tengteng Yan, Ye Chen, Junwu Liu, Dongdong Jian, Ji’e Yang, Likun Ma, Zequn Yin, Houzao Chen, Baofa Sun, Deling Kong, Junbo Ge, Yajun Duan · 2026
Read Hepatic ChREBP Drives Cardiac Remodeling via ApoM Non-transcriptional Repression by Shuang Zhang, Zhenzhen Zhang, Zihan Ma, Wen Wu, Lu Tang, Yanlu Han, Songning Chen, Tengteng Yan, Ye Chen, Junwu Liu, Dongdong Jian, Ji’e Yang, Likun Ma, Zequn Yin, Houzao Chen, Baofa Sun, Deling Kong, Junbo Ge, Yajun Duan (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13608343.txt.
Description
Shuang Zhang and co-authors uncover a liver-to-heart signal that drives harmful heart remodeling, the thickening and scarring that leads to heart failure. In mouse models, a sugar-sensing protein in the liver, ChREBP, rose sharply, while heart levels stayed flat. Removing it only from liver cells protected the heart against two standard remodeling triggers.
The chain runs through a blood protein called ApoM. Without liver ChREBP, the liver released more ApoM into the blood by a secretion route, not by making more of its gene message. Extra ApoM, or the lipoprotein particles carrying it, eased remodeling through a known heart receptor path. The authors propose boosting liver ApoM release as a new treatment angle.
Catalog record
| CREATOR | Shuang Zhang, Zhenzhen Zhang, Zihan Ma, Wen Wu, Lu Tang, Yanlu Han, Songning Chen, Tengteng Yan, Ye Chen, Junwu Liu, Dongdong Jian, Ji’e Yang, Likun Ma, Zequn Yin, Houzao Chen, Baofa Sun, Deling Kong, Junbo Ge, Yajun Duan |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 48 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |