Neurobehavioral Consequences of the 5′-AMP-Induced Torpor-like Hypothermic State
Alessandro Stronati, Giorgia Macchioni, Arianna Racca, Daniela Santucci, Matteo Cerri · 2026
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Description
Alessandro Stronati and colleagues chill mice into a torpor-like state and then test their brains, in this study from twenty twenty-six. A drug, 5-prime-AMP, can drive body temperature and metabolism down in a controlled way. Such a state could shield astronauts on long missions and patients in critical care, if it leaves the mind intact.
Mice brought down this way, with mild cold to help, later ran a memory maze as well as controls: their short-term spatial memory was unharmed. Right after waking they moved less for a while and groomed more, signs of a recovery phase rather than damage. The authors note the state is known to leave a reversible mark on a brain protein also altered in Alzheimer disease, which makes the clean behavior result more notable. Human hopes now rest on careful follow-up testing.
Catalog record
| CREATOR | Alessandro Stronati, Giorgia Macchioni, Arianna Racca, Daniela Santucci, Matteo Cerri |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 50 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |