Injectable Hydroxyapatite and Tetracalcium Phosphate Granules Combined with Autologous Bone Marrow Concentrate: Toward Shape-Adaptive, Single-Step Bone Regeneration
Melania Maglio, Maria Sartori, Annapaola Parrilli, Lucia Martini, Enrico Lucarelli, Michela Pierini, Chiara Bellotti, Marzio Piccinini, Susanna Prosperi, Milena Fini, Gianluca Giavaresi · 2026
Read Injectable Hydroxyapatite and Tetracalcium Phosphate Granules Combined with Autologous Bone Marrow Concentrate: Toward Shape-Adaptive, Single-Step Bone Regeneration by Melania Maglio, Maria Sartori, Annapaola Parrilli, Lucia Martini, Enrico Lucarelli, Michela Pierini, Chiara Bellotti, Marzio Piccinini, Susanna Prosperi, Milena Fini, Gianluca Giavaresi (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13608013.txt.
Description
Bone defects with odd shapes need grafts that flow in and then hold, and a sheep study tests one such mix in 2026. Melania Maglio and co-authors packed mineral granules, with or without the animal's own marrow concentrate, into standard bone defects. Two granule forms were tried: bare and coated with a seaweed gel. Scans and tissue reads at six and twelve weeks graded the healing.
Bare granules joined with host bone and spurred new growth. The coating eased handling but changed how the granules sat and broke down. Bare granules plus marrow gave the best bone contact and volume at twelve weeks. A direct marrow effect alone did not reach firm statistical ground. The authors back the bare mix for one-step repair.
Catalog record
| CREATOR | Melania Maglio, Maria Sartori, Annapaola Parrilli, Lucia Martini, Enrico Lucarelli, Michela Pierini, Chiara Bellotti, Marzio Piccinini, Susanna Prosperi, Milena Fini, Gianluca Giavaresi |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 43 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |