Human Macrophage Polarization Dynamics on a 3D Fibrous Polydioxanone Mesh In Vitro
Ana Laura de Senne Zonta, Biagio Matera, Paulo Tambasco de Oliveira, Isabela Rodrigues Gonsales, Carlos Eduardo Santos Melo, Francesca Rossi, Daniela Bazan Palioto, Benedetta Ghezzi · 2026
Read Human Macrophage Polarization Dynamics on a 3D Fibrous Polydioxanone Mesh In Vitro by Ana Laura de Senne Zonta, Biagio Matera, Paulo Tambasco de Oliveira, Isabela Rodrigues Gonsales, Carlos Eduardo Santos Melo, Francesca Rossi, Daniela Bazan Palioto, Benedetta Ghezzi (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13607951.txt.
Description
Ana Laura Zonta and co-authors watch how human macrophages change their behavior on a fibrous mesh meant for tissue repair. Their study appeared in 2026. Macrophages steer healing at the border between body and implant. The mesh is made of a dissolvable polymer spun into fibers like natural tissue scaffolding. Cells grown from a human line were kept on the mesh in three states: resting, attack mode, and repair mode.
Gene activity, marker stains, microscope images, and metabolism checks tracked the cells over four days. Attack signals peaked at three days then faded. Repair markers climbed steadily and led by day four. The cells gripped the mesh well in all states, changing shape with their mode. The authors say the mesh supports the natural swing from attack to repair that healing needs.
Catalog record
| CREATOR | Ana Laura de Senne Zonta, Biagio Matera, Paulo Tambasco de Oliveira, Isabela Rodrigues Gonsales, Carlos Eduardo Santos Melo, Francesca Rossi, Daniela Bazan Palioto, Benedetta Ghezzi |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 50 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |