Endothelial Filamin C Alleviates Atherosclerosis via PINK1/Parkin-Dependent Mitophagy and mtDNA-cGAS-STING Inflammation Suppression
Yongxuan Zhan, Yan Feng, Ting Zhao, Jiapeng Fu, Minghui Chen, Mingli Liu, Yu Cao, Jiaju Li, Xiangqi Meng, Yongli Li · 2026
Read Endothelial Filamin C Alleviates Atherosclerosis via PINK1/Parkin-Dependent Mitophagy and mtDNA-cGAS-STING Inflammation Suppression by Yongxuan Zhan, Yan Feng, Ting Zhao, Jiapeng Fu, Minghui Chen, Mingli Liu, Yu Cao, Jiaju Li, Xiangqi Meng, Yongli Li (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13607726.txt.
Description
Yongxuan Zhan and co-authors uncover a protective role for filamin C in the vessel lining during atherosclerosis. The lining's failure and its poor cleanup of worn-out mitochondria drive plaque growth, but the upstream switches were unclear. The team measured filamin C in 20 pairs of human carotid plaques and healthy vessel tissue. They then tested its action in cultured lining cells and in mice bred to form plaques on a fatty diet.
Filamin C ran low in plaques, in stressed cells, and in diseased mouse aortas. Raising it cut cell death and oxidation, while lowering it worsened both. The protein switches on a cleanup route, PINK1 and Parkin mitophagy, which keeps stray mitochondrial DNA from firing an inflammatory alarm. Blocking that cleanup erased the protection, and boosting the protein in mouse vessels slowed plaque growth.
Catalog record
| CREATOR | Yongxuan Zhan, Yan Feng, Ting Zhao, Jiapeng Fu, Minghui Chen, Mingli Liu, Yu Cao, Jiaju Li, Xiangqi Meng, Yongli Li |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 60 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |