NSD Histone Methyltransferases in Solid Tumors: Biological Functions, Oncogenic Mechanisms and Therapeutic Targeting
Yan-ting Yann Zhang, Andrew Plenn, Joey Sun, Cun Zhang, Phil Evans, Junsong Zhao, Huicong Li, Aurpita Shaha, Xiaodan Yao, Haiying Chen, Francis Spitz, Generosa Grana, Jia Zhou, Shumei Song · 2026
Read NSD Histone Methyltransferases in Solid Tumors: Biological Functions, Oncogenic Mechanisms and Therapeutic Targeting by Yan-ting Yann Zhang, Andrew Plenn, Joey Sun, Cun Zhang, Phil Evans, Junsong Zhao, Huicong Li, Aurpita Shaha, Xiaodan Yao, Haiying Chen, Francis Spitz, Generosa Grana, Jia Zhou, Shumei Song (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13607714.txt.
Description
A family of enzymes that tags histones can reprogramme a tumour's genes, and Yan-ting Zhang and co-authors review the NSD family across solid cancers. The three members write the same chemical mark on histone H3, loosening chromatin and switching programmes for growth, repair, and stability. Each is found mutated, amplified, or overproduced in different tumours, driving invasion, immune evasion, metabolic rewiring, and drug resistance.
Yet the siblings are not interchangeable; each misbehaves by its own route in its own cancers. Drug hunters have answered with selective blockers, reader-protein antagonists, and degrader molecules that destroy the enzymes outright. The review gathers biological functions, cancer mechanisms, and the state of targeting, arguing these enzymes have graduated from curiosities to credible drug targets.
Catalog record
| CREATOR | Yan-ting Yann Zhang, Andrew Plenn, Joey Sun, Cun Zhang, Phil Evans, Junsong Zhao, Huicong Li, Aurpita Shaha, Xiaodan Yao, Haiying Chen, Francis Spitz, Generosa Grana, Jia Zhou, Shumei Song |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 42 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |