Dysregulation of the Heparanase/TFPI-2/Heparan Sulfate Axis in Recurrent Pregnancy Loss
Chen Yanovich, Nadin Sabbah, Keren Asayag, Yonatan Crispel, Haim Cohen, Anat Keren-Politansky, Yona Nadir · 2026
Read Dysregulation of the Heparanase/TFPI-2/Heparan Sulfate Axis in Recurrent Pregnancy Loss by Chen Yanovich, Nadin Sabbah, Keren Asayag, Yonatan Crispel, Haim Cohen, Anat Keren-Politansky, Yona Nadir (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13607651.txt.
Description
Chen Yanovich and six co-authors found a clotting-related axis out of balance in women with repeated miscarriages in a 2026 paper. Recurrent pregnancy loss often stays unexplained after standard clotting checks. The team focused on heparanase, an enzyme that trims sugar chains and promotes clotting, its inhibitor TFPI-2, and the sugar heparan sulfate.
Blood from 69 affected women and 47 controls showed higher heparanase levels, activity, and gene expression in the loss group, plus raised sugar levels and more of the inhibitor too. Certain gene variants tracked with the higher activity. Cell experiments with enzyme-derived peptides probed the mechanism. The authors propose the axis as a hidden contributor to unexplained pregnancy loss.
Catalog record
| CREATOR | Chen Yanovich, Nadin Sabbah, Keren Asayag, Yonatan Crispel, Haim Cohen, Anat Keren-Politansky, Yona Nadir |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 44 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |