Are Platelet Volume, Density, and the Homeostatic Blueprint the Missing Link in Platelet-Rich Plasma Therapies? An Evidence-Based Narrative Review
Peter A. Everts, Luga Podesta, Jane Fitzpatrick, Leonardo P. Oliveira, José Fábio Lana, André van Zundert, Mikel Sánchez, Diego Delgado, Christine Brown Mahoney, Glenn Flanagan, Robert Alexander, Paul Harrison · 2026
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Description
Peter Everts and co-authors ask whether overlooked platelet traits explain the uneven results of platelet-rich plasma therapy, in a 2026 review. The therapy injects a concentrate of a patient's own platelets to aid healing in joints and the spine.
Preparation methods usually focus on devices and delivery, not on the patient's own blood state. The review argues that platelet size, density, and distribution vary with the body's repair balance and change how many reactive platelets a preparation captures. It recommends measuring simple platelet indices before treatment so protocols can preserve the denser, more regenerative platelets. Matching preparation to the patient's biology, the authors suggest, could make outcomes more consistent.
Catalog record
| CREATOR | Peter A. Everts, Luga Podesta, Jane Fitzpatrick, Leonardo P. Oliveira, José Fábio Lana, André van Zundert, Mikel Sánchez, Diego Delgado, Christine Brown Mahoney, Glenn Flanagan, Robert Alexander, Paul Harrison |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 54 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |