Ambient Cold Exposure Modulates B-Cell Distribution via Glucocorticoid-CXCR4 Signaling
Hsuan-Yun Lee, Te-Sheng Lien, Der-Shan Sun, Guan-Ling Lin, Ching-Feng Cheng, Ko-Nien Shih, Hsin-Hou Chang · 2026
Read Ambient Cold Exposure Modulates B-Cell Distribution via Glucocorticoid-CXCR4 Signaling by Hsuan-Yun Lee, Te-Sheng Lien, Der-Shan Sun, Guan-Ling Lin, Ching-Feng Cheng, Ko-Nien Shih, Hsin-Hou Chang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13607329.txt.
Description
Lee and colleagues show in twenty twenty-six that cold air reshuffles where B cells sit in the body, through a stress-hormone pathway. Immune cells patrol between blood, spleen, and marrow, but how everyday stressors move them was unclear. Mice kept in the cold, or given a steroid drug, lost B cells from the blood and their spleens shrank, without the cells dying.
Labelled-cell transfers showed the missing B cells had moved into the bone marrow. Cold raised the stress hormone, which boosted a homing receptor on B cells; blocking that receptor largely stopped the migration. The authors propose the marrow as a sheltered reservoir during stress, saving energy for heat-making. The pathway may matter for B-cell autoimmune disease care.
Catalog record
| CREATOR | Hsuan-Yun Lee, Te-Sheng Lien, Der-Shan Sun, Guan-Ling Lin, Ching-Feng Cheng, Ko-Nien Shih, Hsin-Hou Chang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 45 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |