Exploring the Toxicological Impacts of DOTP Exposure on Pulmonary Arterial Hypertension via Network Toxicology, Virtual Knockout, Molecular Docking and Experimental Validation
Xiaoying Wang, Xiaoyu Jiang, Zhijun Li, Yingjie Wang, Xiangyang Qin · 2026
Read Exploring the Toxicological Impacts of DOTP Exposure on Pulmonary Arterial Hypertension via Network Toxicology, Virtual Knockout, Molecular Docking and Experimental Validation by Xiaoying Wang, Xiaoyu Jiang, Zhijun Li, Yingjie Wang, Xiangyang Qin (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13607242.txt.
Description
Xiaoying Wang and co-authors probe how a common plasticizer might contribute to a serious lung vessel disease, in a study from 2026. The chemical, called DOTP, is used in many daily products, and exposure is widespread. The disease in question, pulmonary arterial hypertension, scars and narrows the lung's arteries, and its environmental triggers are poorly mapped.
The team combined network analysis of chemical and gene data with computer simulations and lab checks. Four core target proteins emerged where the chemical's effects may converge. Virtual switch off tests on those targets disturbed pathways tied to damage and movement of the artery lining cells. Docking studies and cell experiments then checked the proposed links. The work builds a testable chain from exposure to disease mechanism.
Catalog record
| CREATOR | Xiaoying Wang, Xiaoyu Jiang, Zhijun Li, Yingjie Wang, Xiangyang Qin |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 33 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |