Neutrophil Extracellular Traps in the Tumor Microenvironment: Mechanisms, Immune Regulation, and Implications for Immune Checkpoint Inhibitor Therapy
Chung-Wen Kuo, Hsin-Ying Clair Chiou, Shih-Yu Huang, Chia-Che Wu, Yu-Li Su · 2026
Read Neutrophil Extracellular Traps in the Tumor Microenvironment: Mechanisms, Immune Regulation, and Implications for Immune Checkpoint Inhibitor Therapy by Chung-Wen Kuo, Hsin-Ying Clair Chiou, Shih-Yu Huang, Chia-Che Wu, Yu-Li Su (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13607139.txt.
Description
Five authors, led by Chung-Wen Kuo, review neutrophil extracellular traps in cancer in this 2026 paper. Neutrophils are white blood cells, and under tumor signals they can cast out web-like fibers of DNA and proteins. These traps, called NETs, now look like key players in the tissue around a tumor.
Inside that tissue, the traps reshape the stroma that supports the tumor. They blunt the attack of killer T cells, natural killer cells, and dendritic cells. They also push other immune cells toward states that favor the tumor, and they can shield tumor cells from direct attack. By carrying the PD-L1 protein, the traps can tire out T cells and shut them out of the tumor. The review weighs what this means for checkpoint inhibitor drugs, a main class of cancer immunotherapy.
Catalog record
| CREATOR | Chung-Wen Kuo, Hsin-Ying Clair Chiou, Shih-Yu Huang, Chia-Che Wu, Yu-Li Su |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 56 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |