Genomic Stress and DNA Repair During Macrophage Differentiation and Inflammatory Activation
Seo-Gyeong Jo, Jeseok Jeon, Yeon-Ji Jeon, Sun-Ju Park, Tae-Hong Kang · 2026
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Description
Seo-Gyeong Jo and co-authors review how immune cells guard their DNA while doing stressful work in this 2026 paper. The cells, macrophages, fight germs and support tissue, but their own activity can harm DNA. Fiery chemistry, heavy gene use, and cell growth all strain the genome.
The review tracks how repair shifts as these cells mature and switch on. Two repair paths grow stronger, one for small base damage and one for double-strand breaks. A third path, which fixes bulky damage, can weaken. The authors weigh how this mix shapes immune work. It frames a trade-off built into the cells.
Catalog record
| CREATOR | Seo-Gyeong Jo, Jeseok Jeon, Yeon-Ji Jeon, Sun-Ju Park, Tae-Hong Kang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 52 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |