Elevated dNTP Pool Levels Impair Homologous Recombination and Enhance Glioblastoma Sensitivity to Irradiation and Temozolomide
Dominique Monroe, Mercy Kehinde-Ige, Arilyn Williams, Vafa Ismayilova, Apeksha Anand, Matthew Kededa, Ramsha Khanam, Aman Kalsi, Ali S. Arbab, Daitoku Sakamuro, Huidong Shi, Waaqo Daddacha · 2026
Read Elevated dNTP Pool Levels Impair Homologous Recombination and Enhance Glioblastoma Sensitivity to Irradiation and Temozolomide by Dominique Monroe, Mercy Kehinde-Ige, Arilyn Williams, Vafa Ismayilova, Apeksha Anand, Matthew Kededa, Ramsha Khanam, Aman Kalsi, Ali S. Arbab, Daitoku Sakamuro, Huidong Shi, Waaqo Daddacha (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13606881.txt.
Description
Dominique Monroe and eleven co-authors find that flooding glioblastoma cells with DNA building blocks weakens their repair system and makes standard treatments work better. Their study came out in 2026. Glioblastoma is an aggressive brain tumor whose cells repair radiation and drug damage unusually well, driving resistance.
Raising the pool of these building blocks, called dNTPs, disrupted the tumor's main repair route for broken DNA. A replication crew that normally builds new DNA was drawn to the damage sites and blocked the repair proteins from gathering. Damage then lingered, growth stalled, and cells died. The effect held even in tumor cells bred to resist radiation and in cells from patients whose cancer returned. The authors propose dNTP levels as a lever for overcoming treatment resistance.
Catalog record
| CREATOR | Dominique Monroe, Mercy Kehinde-Ige, Arilyn Williams, Vafa Ismayilova, Apeksha Anand, Matthew Kededa, Ramsha Khanam, Aman Kalsi, Ali S. Arbab, Daitoku Sakamuro, Huidong Shi, Waaqo Daddacha |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 50 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |