MORG1 Haploinsufficiency Is Associated with Stage- and Sex-Dependent Renoprotection and Signalling Alterations in Diabetic Kidney Disease
Jonas Till Ihle, Luisa Duong, Nadja Ziller, Eric Jankowski, Karin Elflein, Alexander Berndt, Nikolaus Gaßler, Gunter Wolf, Ivonne Loeffler · 2026
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Description
Jonas Till Ihle and eight co-authors test whether halving a scaffolding protein protects diabetic kidneys, and whether the answer changes with stage and sex. Their mouse study was published in twenty twenty-six. Diabetic kidney disease grows with age and type two diabetes, yet what sets kidney vulnerability at each stage is murky.
The team bred mice with one copy of the organizer gene removed into a standard diabetes model. Males and females were checked at early and later stages against non-diabetic controls. Kidney scarring, protein leakage in urine, and key signal activity were measured. The gene cut lowered scarring and leakage early in the disease. Later effects differed. The work shows protection can be real yet time- and sex-limited.
Catalog record
| CREATOR | Jonas Till Ihle, Luisa Duong, Nadja Ziller, Eric Jankowski, Karin Elflein, Alexander Berndt, Nikolaus Gaßler, Gunter Wolf, Ivonne Loeffler |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 32 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |