Unveiling Disulfidptosis and Cuproptosis Vulnerabilities in Pterygium: A Transcriptomic Analysis and In-Silico Drug Repurposing Strategy
İdris Sarıkaya, Recep Kılıç · 2026
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Description
A fleshy growth that creeps across the eye surface resists the usual cell death routes, and two newer death programs may be its weak point. Idris Sarikaya and Recep Kilic explored those programs in this 2026 study of the eye growth called pterygium. Gene activity data came from eight growth samples and eight healthy surface samples in a public dataset.
Fifteen genes of one death program and thirteen of the other were profiled. The team then screened drug databases in the computer for compounds that might hit the altered genes, a repurposing shortcut. The growth often returns after surgery, so a drug that kills its cells selectively would fill a real gap. The paper is a data-first case for testing those drugs in the lab.
Catalog record
| CREATOR | İdris Sarıkaya, Recep Kılıç |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 33 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |