Genetic Evidence for Metabolites Mediated Causal Inference Between Gut Microbiota and Venous Thromboembolism
Pin Huang, Wenxiao Wei, Ying Xiao, Qian Zhu · 2026
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Description
Pin Huang and co-authors use genetics to test whether gut microbes help cause venous thromboembolism, dangerous clots in veins. Their 2026 study applies Mendelian randomization, a method that uses gene variants as natural experiments. The team screened eighty-two gut species for causal links to clotting.
Two species showed positive causal effects that survived many checks. One of them acted partly through blood albumin and omega-3 fatty acids, and that mediation held up in repeat cohorts. Gene mapping tied the species to the handling of those very substances. The findings point to microbe-linked substances as possible targets for safer clot prevention.
Catalog record
| CREATOR | Pin Huang, Wenxiao Wei, Ying Xiao, Qian Zhu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 35 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |