Epigenomic Remodeling by Lipid Metabolism: A Cross-Disease Perspective on Cancer and Brain Disorders
Asma Rafique, Adeel Farooq, Clara E. Cho, Marica Bakovic · 2026
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Description
Rafique, Farooq, Cho, and Bakovic reviewed in twenty twenty-six how fat metabolism rewires the epigenome, the chemical control layer over genes. Fats were once seen mainly as membrane material and fuel. The authors argue fat pathways decide which helper molecules reach the nucleus and which gene states lock in during disease.
They compare cancer with Alzheimer's and Parkinson's diseases. In cancer, fat building and burning feed the molecule pools that tag DNA and histones, helping tumor genes stay on under stress. In brain disease, faulty fat handling in mitochondria, cholesterol, and microglia distorts the gene programs neurons need. The same metabolic nodes can yield very different outcomes by cell type. New single-cell and spatial tools may guide metabolism-targeted epigenetic therapies, they suggest.
Catalog record
| CREATOR | Asma Rafique, Adeel Farooq, Clara E. Cho, Marica Bakovic |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 66 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |