A Seven Amino Acid Long Region in the Cardiac Cav1.2, Encompassing Ser1487, Is Essential for Mice Embryonic Development and “Fight or Flight” Responses
Catherine Jenkins, Henrietta Cserne Szappanos, Agnieszka Dyrda, Teagan S. Er, Filip van Petegem, Livia C. Hool · 2026
Read A Seven Amino Acid Long Region in the Cardiac Cav1.2, Encompassing Ser1487, Is Essential for Mice Embryonic Development and “Fight or Flight” Responses by Catherine Jenkins, Henrietta Cserne Szappanos, Agnieszka Dyrda, Teagan S. Er, Filip van Petegem, Livia C. Hool (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13605837.txt.
Description
Catherine Jenkins and co-authors published a mouse study in 2026 on a tiny region of a heart calcium channel that proves vital for life. The channel drives heartbeat and the fight-or-flight response, tuned by a hormone-linked pathway. Which exact spot on the channel matters was disputed. The team built three mouse models targeting the mouse form of that spot.
A stretch of just seven amino acids around the spot turned out to be key for the channel to fold right. Mice with the change in both gene copies died before birth. The study also confirms that adding a phosphate at that spot is needed for the channel shift behind fight-or-flight. The work settles the region's role.
Catalog record
| CREATOR | Catherine Jenkins, Henrietta Cserne Szappanos, Agnieszka Dyrda, Teagan S. Er, Filip van Petegem, Livia C. Hool |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 47 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |