Hypofractionation in Unresectable Stage II–III NSCLC: A Systematic Technical Review and Practical Recommendations
Gabriela Antelo, Miriam Núñez-Fernández, Josep Carreras, Nuria Farre-Bernardo, Paloma Sosa Fajardo, Inmaculada Romero-Palomar, Nuria Rodríguez de Dios, Arturo Navarro-Martin · 2026
Read Hypofractionation in Unresectable Stage II–III NSCLC: A Systematic Technical Review and Practical Recommendations by Gabriela Antelo, Miriam Núñez-Fernández, Josep Carreras, Nuria Farre-Bernardo, Paloma Sosa Fajardo, Inmaculada Romero-Palomar, Nuria Rodríguez de Dios, Arturo Navarro-Martin (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13605718.txt.
Description
Gabriela Antelo and co-authors published this 2026 technical review on giving lung cancer radiation in fewer, larger doses. For unresectable stage II-III non-small cell lung cancer, chemoradiation followed by a year of durvalumab is standard, yet about a fifth of patients relapse locally. Hypofractionation promises a higher effective dose in less time, and perhaps less damage to circulating immune cells.
Searching four databases under PRISMA rules, the reviewers sort the evidence by who benefits and by the technical conditions for safety: contouring margins, dose constraints, and pairing with systemic therapy. Studies divide into photon and non-photon, concurrent and not. The output is practical recommendations rather than a verdict, a map for clinics weighing shorter courses against organs at risk. The aim throughout is a better therapeutic ratio without new toxicity.
Catalog record
| CREATOR | Gabriela Antelo, Miriam Núñez-Fernández, Josep Carreras, Nuria Farre-Bernardo, Paloma Sosa Fajardo, Inmaculada Romero-Palomar, Nuria Rodríguez de Dios, Arturo Navarro-Martin |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 36 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |