Border-Associated Macrophage Migrasomes in Alzheimer’s Disease: An Emerging Aβ–Senescence–Microglia Axis?
James Chmiel, Marta Kopańska · 2026
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Description
James Chmiel and Marta Kopańska review a possible new player in Alzheimer's disease: guard cells that sit at the brain's borders, in a paper published in 2026. These cells handle sticky amyloid near blood vessels and watch for threats. Aging and vessel amyloid may push them into worn, stressed states.
The review links two lines of evidence. In one, amyloid triggers a surface switch on the guard cells that makes harmful oxygen chemicals and hurts vessel function. In the other, the cells shed tiny moving parcels loaded with a protein that can damage the vessel wall and pass worn traits to other brain immune cells. The authors are careful about limits: human proof is strongest for vessel amyloid, not Alzheimer's as a whole.
Catalog record
| CREATOR | James Chmiel, Marta Kopańska |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 128 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |