Extrapolation of Adult Evidence to Pediatric Practice: Bridging the Gap in Pediatric Heart Failure Pharmacotherapy
Adelina-Mihaela Sorescu, Cristina Isabel Viorica Ghiță, Smaranda Stoleru, Gabriela Duică, Alin Marcel Nicolescu, Eliza Elena Cinteză, Ion Fulga, Oana Andreia Coman · 2026
Read Extrapolation of Adult Evidence to Pediatric Practice: Bridging the Gap in Pediatric Heart Failure Pharmacotherapy by Adelina-Mihaela Sorescu, Cristina Isabel Viorica Ghiță, Smaranda Stoleru, Gabriela Duică, Alin Marcel Nicolescu, Eliza Elena Cinteză, Ion Fulga, Oana Andreia Coman (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13605619.txt.
Description
Adelina-Mihaela Sorescu and seven co-authors wrote a 2026 review on borrowing adult heart failure evidence for children. Pediatric heart failure carries heavy illness and death, yet child-specific drug evidence is scarce. Adult care was transformed by large trials proving several drug classes. Children's trials, by contrast, are small and mixed, with inconclusive results.
In practice, children's treatment is extrapolated from adult studies. The authors warn that growing hearts differ in structure, hormone signaling, and drug handling, so adult doses and benefits may not transfer cleanly. The review maps where extrapolation is reasonable and where it is risky. It discusses the proven adult arsenal, from ACE inhibitors to SGLT2 inhibitors, against the thin pediatric record. Bridging that gap carefully is the paper's plea.
Catalog record
| CREATOR | Adelina-Mihaela Sorescu, Cristina Isabel Viorica Ghiță, Smaranda Stoleru, Gabriela Duică, Alin Marcel Nicolescu, Eliza Elena Cinteză, Ion Fulga, Oana Andreia Coman |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 44 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |