Rapid Generation of High-Affinity Rabbit Anti-Mouse IgG Monoclonal Antibodies by High-Throughput Single-B-Cell Sorting and Recombinant Expression
Ying Fu, Fang Li, Hengping Wang, Xueyuan Wang, Huiyan Wang · 2026
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Description
Ying Fu and co-authors describe a fast route to high-quality rabbit antibodies in a 2026 methods paper. Rabbit monoclonal antibodies are prized in research and diagnostics for their strong binding and wide target range. Finding the best ones usually takes long, stepwise screening.
The team built a workflow that sorts single B cells at high speed and then expresses the antibodies in the lab. Three rabbits were immunized with mouse antibodies as a test target, and the best responder went through the full pipeline. The linked workflow ties each antibody's traits to its source cell, speeding discovery.
Catalog record
| CREATOR | Ying Fu, Fang Li, Hengping Wang, Xueyuan Wang, Huiyan Wang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 47 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |