Glutamine and Pediatric Intestinal Barrier Function: A Scoping Review of Clinical Evidence and Research Gaps
Dejan Dobrijević, Nataša Nastić, Kristian Pastor · 2026
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Description
Dejan Dobrijevic, Natasa Nastic, and Kristian Pastor review what is known about glutamine and gut barrier health in children, in a review published in two thousand twenty-six. Glutamine is a building block of protein that feeds gut lining cells, and it has been proposed as a way to keep the gut wall tight. The team searched three databases and kept eighteen papers covering fifteen child groups.
Results were mixed across every outcome. Gut leak tests showed gains in some groups, none in others, and brief gains in a few. Proof for stopping germ spread across the gut wall was thin and showed no clear benefit. Gains in gut growth came mostly from weak study designs. No major safety worry stood out, but safety data were sparse. The authors say a uniform benefit is not supported.
Catalog record
| CREATOR | Dejan Dobrijević, Nataša Nastić, Kristian Pastor |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 38 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |