Preclinical In Vitro Evaluation of an Innovative Nutraceutical Mixture Modulating the Histamine H1 Receptor—Preliminary Data
Franco Frati, Carlo Cavaliere, Francesco Frati, Giulio Torello, Marianna Colasante, Chiara Caputo, Marta Scquizzato, Simonetta Masieri · 2026
Read Preclinical In Vitro Evaluation of an Innovative Nutraceutical Mixture Modulating the Histamine H1 Receptor—Preliminary Data by Franco Frati, Carlo Cavaliere, Francesco Frati, Giulio Torello, Marianna Colasante, Chiara Caputo, Marta Scquizzato, Simonetta Masieri (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13605393.txt.
Description
Allergy symptoms fire when histamine switches on its H1 receptor, and a blend of plant extracts and friendly bacteria might turn that switch down. Franco Frati and seven co-authors test the blend in lab cells in a 2026 preliminary study. The mix joins quercetin, perilla, boswellia, blackcurrant, feverfew, helichrysum, and two probiotic strains.
Gene tests showed the mix cut expression of the receptor's gene by about a third against the control. A second assay found the blend lowered release of IP3, the cell's internal messenger in the allergy pathway, by about 10 percent against an activated control. Both effects point the same way: less receptor made, and less signal passed on. The authors present the dish-level results as a first step, with animal and human tests still ahead before any allergy claim can stick.
Catalog record
| CREATOR | Franco Frati, Carlo Cavaliere, Francesco Frati, Giulio Torello, Marianna Colasante, Chiara Caputo, Marta Scquizzato, Simonetta Masieri |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 36 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |