Targeting TGFBR1 with the Investigational Inhibitor TP-6379 Improves Hematopoiesis in Low-Risk MDS Ex Vivo
Tiffany Razabdouski, Robert Dalton, Alexandra Calescibetta, Sean Christiansen, Grace Ward, Anthony C. Augello, Jungwon Moon, Seongseok Yun, Nicole Vincellette, Gabriela Wright, Annelise J. Glode, Dung-Tsa Chen, Jodi Kroeger, Jason M. Foulks, Steven L. Warner, Bin Duan, Bo Liu, Kenneth L. Wright, Eri · 2026
Read Targeting TGFBR1 with the Investigational Inhibitor TP-6379 Improves Hematopoiesis in Low-Risk MDS Ex Vivo by Tiffany Razabdouski, Robert Dalton, Alexandra Calescibetta, Sean Christiansen, Grace Ward, Anthony C. Augello, Jungwon Moon, Seongseok Yun, Nicole Vincellette, Gabriela Wright, Annelise J. Glode, Dung-Tsa Chen, Jodi Kroeger, Jason M. Foulks, Steven L. Warner, Bin Duan, Bo Liu, Kenneth L. Wright, Eri (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13605333.txt.
Description
Razabdouski and colleagues present a study from twenty twenty-six on a test drug that restores blood making in a bone marrow disease. In this disease, immune attack kills off young blood cells. A growth signal, TGF beta, floods the marrow as part of that attack. The team test three drugs that block related signal switches on patient marrow cells. Only the drug aimed at one switch, TGFBR1, restored blood making well. Samples with certain gene splicing flaws responded best to that drug.
The drug also rescued healthy marrow cells harmed by a disease-linked protein. In mice bred to mimic the disease, the drug worked in the body too. A lab cell line showed the same pattern. The authors say direct blockade of that switch is a strong lead.
Catalog record
| CREATOR | Tiffany Razabdouski, Robert Dalton, Alexandra Calescibetta, Sean Christiansen, Grace Ward, Anthony C. Augello, Jungwon Moon, Seongseok Yun, Nicole Vincellette, Gabriela Wright, Annelise J. Glode, Dung-Tsa Chen, Jodi Kroeger, Jason M. Foulks, Steven L. Warner, Bin Duan, Bo Liu, Kenneth L. Wright, Eri |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 48 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |