Candidate Spatial Niches Associated with Gastric Cancer Metastasis and Treatment Resistance: Functional Classification, Evidence Boundaries, and a Translational Framework
Yi Huang, Jingcheng Zhang, Jiaheng Lou, Bo Bian, Mingsi Zhang, Taowei Gou, Tao Jiang, Guangji Zhang · 2026
Read Candidate Spatial Niches Associated with Gastric Cancer Metastasis and Treatment Resistance: Functional Classification, Evidence Boundaries, and a Translational Framework by Yi Huang, Jingcheng Zhang, Jiaheng Lou, Bo Bian, Mingsi Zhang, Taowei Gou, Tao Jiang, Guangji Zhang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13605211.txt.
Description
Yi Huang and seven co-authors propose a framework for spatial niches in gastric cancer in this 2026 paper. Tumors spread and resist drugs unevenly across their space, yet a cluster of cells is not a niche by itself. The authors set a four part test: a defined spatial context, neighborhoods mapped by stated rules, local gene programs that match those neighborhoods, and a link to malignant traits or patient outcomes. Resistance here covers nonresponse, low sensitivity, poor drug delivery, and regrowth.
Four candidate niches emerge inside primary tumors: the invasive front, immune exclusion zones, low oxygen metabolic zones, and vessel support zones. Evidence strength varies by type. Immune exclusion niches tie best to treatment response data. No candidate yet has full clinical validation. The authors offer the scheme to standardize terms and guide the testing that translation would need.
Catalog record
| CREATOR | Yi Huang, Jingcheng Zhang, Jiaheng Lou, Bo Bian, Mingsi Zhang, Taowei Gou, Tao Jiang, Guangji Zhang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 60 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |