MicroRNA-Mediated Regulation of Ionizing Radiation Responses: Mechanisms and Advances in Clinical Translation
Keying Lian, Quan Ma, Xiao Mo, Zhisheng Jiang, Yun Ma · 2026
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Description
Lian and co-authors review how microRNAs steer the body's response to ionizing radiation, in a 2026 paper. MicroRNAs are short RNA strands that tune gene activity after genes are read. Radiation damages DNA directly and through side chemistry, triggering repair, cell cycle pauses, or cell death. MicroRNAs shift their levels after exposure and shape which of those paths a cell takes.
The review covers how these molecules could gauge radiation damage, predict how a tumor will answer radiotherapy, and serve as treatments themselves. Barriers remain: each microRNA hits many targets, effects vary by tissue, and delivery into the body is hard. The authors look to combined omics data and AI analysis to map the network and move the field toward precision radiology.
Catalog record
| CREATOR | Keying Lian, Quan Ma, Xiao Mo, Zhisheng Jiang, Yun Ma |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 29 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |