Palmitoylethanolamide as an Intestinal Gatekeeper: Linking Inflammation, Angiogenesis and Colorectal Cancer Interception
Irene Palenca, Giovanni Sarnelli, Giuseppe Esposito · 2026
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Description
Palenca, Sarnelli, and Esposito make the case for a natural fat-like molecule as a guardian of the colon. Palmitoylethanolamide, made by the body on demand, calms inflammation and, in this perspective, also restrains the blood vessel growth that helps tumors thrive. The colon, where chronic inflammation can slide into cancer, is the test bed for the argument.
Animal and cell evidence now goes beyond theory. A finely ground form of the molecule slows colon cancer cell growth and cuts precancerous lesions in mice. An engineered probiotic that produces it locally shrinks tumor burden and vessel growth in colitis-linked cancer. The authors propose boosting this signal, by supplement or by local production, as an interception strategy, while noting the evidence is still preclinical.
Catalog record
| CREATOR | Irene Palenca, Giovanni Sarnelli, Giuseppe Esposito |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 36 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |