Kukoamine B, a Lycium-Derived Polyamine Alkaloid, Attenuates High-Fat-Diet-Induced Skeletal Muscle Dysfunction with the Involvement of LPS/TLR4/NF-κB-Mediated Metabolic Inflammation
Shunling Yuan, Jiaxin Liu, Lihan Lin, Yiping Liu, Shan Xu, Liangwu Qiu · 2026
Read Kukoamine B, a Lycium-Derived Polyamine Alkaloid, Attenuates High-Fat-Diet-Induced Skeletal Muscle Dysfunction with the Involvement of LPS/TLR4/NF-κB-Mediated Metabolic Inflammation by Shunling Yuan, Jiaxin Liu, Lihan Lin, Yiping Liu, Shan Xu, Liangwu Qiu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13604861.txt.
Description
Shunling Yuan and co-authors test a plant compound called kukoamine B in mice fed a high fat diet in a 2026 study. Such diets cause lipid problems, low grade inflammation, and muscle dysfunction. The compound, from the Lycium plant, has reported anti inflammatory and antioxidant effects.
Mice received the compound by mouth for twelve weeks. Treated mice had less fat and collagen in muscle, less fiber damage, and better strength and endurance. Gene data showed calmer inflammatory paths. Levels of a bacterial toxin fell, and its signaling path was blocked. A known blocker of that path gave similar benefits.
Catalog record
| CREATOR | Shunling Yuan, Jiaxin Liu, Lihan Lin, Yiping Liu, Shan Xu, Liangwu Qiu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 48 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |