The Flexible Peripheral Segments Modulate the Catalytic Activity of the FAD-Containing Monooxygenase EthA from Mycobacterium tuberculosis
Dafeng Liu, Xieping Sun, Feng Yu, Hongying Song, Wenshuang Yao, Huashui Deng, Daoqi Song · 2026
Read The Flexible Peripheral Segments Modulate the Catalytic Activity of the FAD-Containing Monooxygenase EthA from Mycobacterium tuberculosis by Dafeng Liu, Xieping Sun, Feng Yu, Hongying Song, Wenshuang Yao, Huashui Deng, Daoqi Song (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13604814.txt.
Description
Dafeng Liu and co-authors study an enzyme in the tuberculosis bacterium in this 2026 study. The enzyme, called EthA, switches on a key TB drug inside the cell. Drug-resistant TB is a growing threat, yet how this enzyme works in fine detail was unclear, which limits efforts to improve the drug or beat resistance.
The team built a predicted three-part model of the enzyme and tested changes at single spots. One spot proved vital: swapping it killed the enzyme's action. Three other swaps cut action five to seven fold. Cutting off three loose edge parts, by contrast, raised action. The authors say these loose parts likely act as brakes, and they offer the model as a base for drug design.
Catalog record
| CREATOR | Dafeng Liu, Xieping Sun, Feng Yu, Hongying Song, Wenshuang Yao, Huashui Deng, Daoqi Song |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 38 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |